Gore A C and Crews D Environmental Endocrine Disruption of Brain and Behavior
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منابع مشابه
Transgenerational Epigenetic Programming of the Brain Transcriptome and Anxiety Behavior
Embryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination promotes an epigenetic reprogramming of the male germ-line that is associated with transgenerational adult onset disease states. Further analysis of this transgenerational phenotype on the brain demonstrated reproducible changes in the brain transcriptome three generations (F3) removed from the exposure. ...
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A.C. Gore a J. Balthazart b D. Bikle c D.O. Carpenter d D. Crews e P. Czernichow f E. Diamanti-Kandarakis g R.M. Dores h D. Grattan i P.R. Hof j A.N. Hollenberg k C. Lange l A.V. Lee m J.E. Levine n R.P. Millar o R.J. Nelson p M. Porta q M. Poth r D.M. Power s G.S. Prins t E.C. Ridgway u E.F. Rissman v J.A. Romijn w P.E. Sawchenko x P.D. Sly y O. Söder z H.S. Taylor aa M. Tena-Sempere ab H. Vau...
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How an individual responds to the environment depends upon both personal life history as well as inherited genetic and epigenetic factors from ancestors. Using a 2-hit, 3 generations apart model, we tested how F3 descendants of rats given in utero exposure to the environmental endocrine-disrupting chemical (EDC) vinclozolin reacted to stress during adolescence in their own lives, focusing on se...
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In this article we consider the importance of assessing endocrine disruption in a large new cohort that has been proposed, the National Children's Study (NCS). We briefly review evidence that endocrine disruption is a potentially important hypothesis for human studies and weigh the need to assess endocrine disruption in the NCS. We note the salient features of earlier, similar cohort studies th...
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A central goal of green chemistry is to avoid hazard in the design of new chemicals. This objective is best achieved when information about a chemical's potential hazardous effects is obtained as early in the design process as feasible. Endocrine disruption is a type of hazard that to date has been inadequately addressed by both industrial and regulatory science. To aid chemists in avoiding thi...
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